Prince of Wales Hospital, Sydney, NSW
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Head and Neck Cancer Foundation

Reflections of a senior paediatric and adult head and neck surgeon

We interviewed Doctor Ian Jacobson, a senior paediatric and adult head and neck surgeon at Prince of Wales hospital with a particular interest in paediatric otolaryngology and head and neck oncology. As a member of the board of directors at the Head and Neck Cancer Foundation, he believes that self-reflection and research is imperative in any profession, but all the more so in the medical sphere.

From your perspective as a senior ENT surgeon, why do you think research into head and neck cancer is important?

Unless we constantly re-evaluate what we do, we do not learn from our previous misconceptions. When I was a young doctor, surgical treatments were often based on opinion and dogma. Fortunately, during my practising lifetime that has changed substantially.

What kinds of gains do you think need to be made in the field of paediatric otolaryngology to improve the lives of children suffering from ENT problems?

We need evidence. Data derived from large studies or metanalysis of previous research is increasingly providing guidance on appropriate treatment options. International, evidence-based treatment paradigms are emerging for many of the common conditions in paediatric ear nose and throat surgery. It is incredibly useful to be able to say to a parent, “based on specific research, or a well-researched international guideline the right treatment for your child is as follows…!”

How do you think the research the Head and Neck Cancer Foundation supports can make a tangible positive impact on clinical outcomes for your patients?

Australia has a rich tradition of research in Otolaryngology Head and Neck surgery and our research group has contributed significantly to that in the last few years. Our group is currently investigating a number of innovative treatments of direct application to several diseases in the head and neck region. The early work is promising, and we hope it will translate to improving the delivery of healthcare to millions of people worldwide.

What initiative of the Head and Neck Cancer Foundation are you most excited about and why?

Our monthly research meeting is an inspiring experience. Imagine a group of individuals spanning all stages of their medical career from student to senior members perhaps at the twilight of their career meeting in an egalitarian setting. You have the combination of several decades of clinical and academic experience together with youthful vigour and a thirst for new knowledge. It is inspiring to see our medical students and junior postgraduate doctors take hold of an idea and run with it while their peers and senior members at the meeting provide guidance. It truly is an exciting meeting each time.

What do you hope the Head and Neck Cancer Foundation grows into in the next five years?

The Head and Neck Cancer Foundation has grown from a standing start significantly in the last three years. I am hoping that the Head and Neck research group will grow both in numbers and in reach. I envisage biomedical engineers, basic scientists, members of the allied health medical professions and ethicists all participating in research under the umbrella of the Head and Neck Cancer Foundation. Some of our members have already collaborated with research groups overseas and interstate. We are hoping that will continue to grow.

A game-changer for pain relief

Dr Anders Sederis (our 2019 grant recipient) recently completed his masters thesis in a biodegradable novel mesh impregnated with nanoparticles to prevent pain and optimise healing after tonsillectomy.

This project is part of a group of research projects directed by Professor Havas in the development of novel technologies to treat and improve the quality of life not only of patients with head and neck cancers but also patients undergoing necessary common operations.

The Prince of Wales Hospital Foundation has very generously provided seeding capital for this project to go to second-stage animal studies. We are optimistic of being in a position to commence clinical trials mid to late-2022.

Doctor Catherine Meller on the importance of head and neck cancer visibility and work-life balance

This week, we interviewed Head and Neck Cancer Foundation co-director Doctor Catherine Meller. Learn more about how she balances being an Otolaryngologist and facial reconstructive surgeon as well a mother of three as she passionately advocates for increased visibility and funding for head and neck cancer research in Australia.

What motivated you to get involved with the Head and Neck Cancer Foundation?

I’ve always enjoyed the charitable aspects of working in healthcare, and then a great opportunity presented itself to become part of something that I feel is a very under-resourced area in medicine. For many years, enthusiastic young doctors have come through the system with wonderful ideas but very few resources to enable them. The prospect of raising funds to allow brilliant young minds to research and extend the boundaries of what we know about head and neck cancer is a very worthwhile cause that I have jumped at the opportunity to be a part of.

Why do you think Head and Neck Cancer research needs more visibility and funding in Australia?

Head and neck cancers makes up about five percent of all cancers in Australia, but it is a very disfiguring disease that impacts upon our ability to speak breathe or eat properly. As a facial plastics and reconstructive surgeon, I get to see first-hand how life saving surgery and other treatments for cancer can have lasting negative psychological impacts on the patient. Patients are often distressed about their inability to enjoy a meal, or very self-conscious about how their face may look after surgery or radiotherapy. This can often lead to them withdrawing from society and experiencing extreme isolation and loneliness. Ultimately, the terrible impact that head and neck cancer can have on many people is sometimes rendered invisible because of this. I believe it is our responsibility to raise awareness and funding in a meaningful way for a group of patients who so desperately need it.

What has your experience been as a woman in the highly male-dominated world of ENT surgery?

Interesting! I’m really pleased to report that there are more women joining the ranks as they come through training. That said, when I was training myself, I only came into contact with two female ENT surgeons over my five years of training in nine different hospitals in New South Wales. I didn’t really have a role model in an ENT female surgeon per se, but what I did have (and now fully appreciate the significance of) were male champions. These are colleagues who promote fairness, equality, and are willing to stand up for female surgeons in a male dominated field. In fact, I was actively encouraged to join Prince of Wales to contribute a different perspective and have my own voice in what was, prior to my appointment, an entirely male department. The world of surgery is becoming an increasingly diverse place, and it is an exciting time to be a part of it.

How do you maintain a work-life balance as a successful ENT surgeon and mother?

This is one of the most difficult questions I have to answer regularly. I don’t think I’ll ever get it quite right, but that is because I love my family and I am also extremely passionate about my job. There are different parts of me that feel fulfilled by each of these roles, and I try to take it week by week. The thing about young kids is that life is often quite unpredictable and can change daily – as in what they need from you as a parent. Ultimately that comes first, but the truth is that I wouldn’t be able to enjoy my career without having a lot of family support. I’m very privileged to enjoy that position, and having regular pulse checks on the state of our household between me and my husband, who is doing what and going where, is also very helpful!

What advice/words of wisdom would you give young women wanting to get involved in ENT surgery?

It’s a wonderful field, and a very rewarding career. I would encourage anyone to go for it as soon as you know that it is truly what you want to do. I always get asked questions like, “but when is it a good time to have kids“, or “but what about if I want to get married and take some time off?“. My experience is this – there will always be reasons not to pursue a career in surgery. It is very difficult on both you and your support network. It is also exhausting, both emotionally and financially. Only you will know whether it is truly worth it.

If you’ve made the decision to commit yourself to a career in surgery, then I promise you, everything else can be worked out. Not without sacrifice and determination mind you, but it can be done.

Facial Palsy Awareness Week

In honour of Facial Palsy Awareness Week from March 1 to March 7, we interviewed facial palsy specialist and member of the board of the Head and Neck Foundation, Doctor Catherine Meller.

What is facial palsy?

Facial palsy (FP) generally refers to weakness of the facial muscles, mainly resulting from temporary or permanent damage to the facial nerve.

When a facial nerve is either non-functioning or missing, the muscles in the face do not receive the necessary signals to allow them to function properly. This results in paralysis of the affected part of the face, which can affect the movement of the eye(s) and/or the mouth, as well as other areas.

Although the most commonly known cause of facial paralysis is Bell’s palsy, there are actually many different causes of facial palsy, and treatment and prognosis vary greatly depending on the cause.

What are the symptoms of Facial Palsy (FP)?

Facial palsy causes many physical problems, including asymmetry of the face, problems closing the eye, difficulty eating and drinking, and trouble with speaking clearly.

It also has devastating emotional effects. Patients lose the ability to smile and are often perceived as ‘negative’ or ‘angry’. Patients with FP may have trouble displaying emotion, causing miscommunication and self-consciousness. Patients frequently suffer from anxiety and depression as a result of the functional and cosmetic aspects of FP.

What is the Prince of Wales Facial Nerve and Facial Reconstruction Clinic?

I founded the Prince of Wales Facial Nerve Clinic in 2018 because I am passionate about rehabilitating and treating patients with facial nerve injuries. The clinic is the only one of its kind in NSW and includes real-time diagnostic nerve tests thanks to an ENoG machine donated through the Prince of Wales Hospital Foundation. It allows us to rapidly diagnose nerve injuries, and begin treatment straight away to give patients the best possible chance of regaining full function of their nerve.

For patients who suffer from permanent nerve injury, we offer on-the-spot Facial Nerve Physiotherapy, hearing tests, counselling services, botox treatment for muscle spasms and synkinesis, and speech therapy. Some patients may benefit from surgery to ‘reanimate’ the face, using donor nerves and/or muscles, and these are performed at Prince of Wales Hospital using cutting-edge techniques and technology.

Pictured: Doctor Catherine Meller using the ENoG machine in the clinic to diagnose facial palsy and instigate rapid treatment.

Thalia’s Story

When Thalia was 19 years old, she became very unwell with a weakness of her muscles that rapidly spread throughout her body. She was rushed to the hospital and cared for in ICU, and diagnosed with Guillan Barre Syndrome.

Pictured: Thalia before her diagnosis with Guillain-Barré syndrome (GBS).

Guillain-Barré syndrome (GBS) is a condition affecting the nerves that control our senses and movements (peripheral nerves) including the facial nerve. They leave the brain and spinal cord and carry impulses to and from the rest of the body.

The cause of GBS is unclear. Normally when we develop an infection, the body’s natural defense system produces “antibodies” which attack and kill viruses and bacteria. GBS causes this natural defense system to become out of control, and antibodies start to attack the body itself, specifically, the protective covering of the nerves. Once this is damaged, the nerve can no longer send signals to your muscles or organs to enable them to perform the jobs they normally carry out.

Over a period of many weeks, most of Thalia’s nerves recovered. Unfortunately, her facial nerves to both sides of her face were left weakened, and despite physiotherapy, Thalia has been left with an impaired ability to show emotion, in particular, positive emotions including smiling and laughing.

Pictured: Thalia after her diagnosis with Guillain-Barré syndrome (GBS).

Thalia was referred to the Prince of Wales Facial Nerve Clinic by her neurologist. She has recently undergone a procedure to improve her ability to smile, by using another nerve (one that controls the muscles that help us chew) to ‘supercharge’ the weakened facial nerve. She is in the process of training her brain to use this nerve to power her smile, through specialised physiotherapy. Thalia is passionate about raising awareness of this condition and is currently completing tertiary university studies in the field of forensic sciences.

Why is Facial Palsy Week important?

Facial Palsy (FP) can significantly impact a patient’s psychological as well as physiological health. Facial expressions are a crucial way of relating to the world, and when one’s ability to express themselves in line with how one is feeling is taken away, it can lead to a lack of social connection, social isolation, anxiety, and depression. The Prince of Wales’ Facial Nerve and Facial Reconstruction Clinic helps patients regain control of their facial expressions and empowers them to reconnect with others in this essential but too often forgotten way.

Fordham School of Translational Medicine

Our multi-disciplinary, problem solving-focused vision: A school of translational medicine in Otolaryngology, Head and Neck Surgery

The traditional definition of translation medicine focuses on translating medical advances from the laboratory to bedside. However, at the Head and Neck Cancer Foundation, we have a different vision that begins by identifying a clinical need.

“We’re all about looking after patients, treating clinical conditions, getting some insight into where we’re providing good treatment, and understanding where we’re not, so we can work backward to fill a need,” says Professor Thomas Havas.

Although Otolaryngology, Head and Neck Surgery is far from the glamour areas of science research, approximately every third visit to a General Practitioner is for an ENT-related issue. There is huge prevalence with massive community cost and treatments are often more profit-focused than problem-focused.

Professor Havas explains a practical application of this.

“About ten years ago, it started to become popular to wash your nose out with saltwater spray. There’s no good evidence that it achieves anything and yet last year in America, Americans spent over $2000 million buying saltwater to wash their nose out with. It’s not science-based but profit-based and it’s usually the manufacturers of the saltwater spray who hire a couple of prominent Otolaryngologists with a significant financial incentive to spruik a product with little evidence backing it up,” he says.

The future School of Translational Medicine in Otolaryngology, Head and Neck Surgery will focus on science-driven solutions to clinical needs as opposed to the current framework that is too often fear and economically driven. We will create an independent school with academic credibility, staffed by senior Otolaryngologists and researchers who appreciate that the hackneyed commercially-driven approach is no longer appropriate.

“The school will provide a grassroots approach ranging from common problems to innovative treatments for Head and Neck Cancer. It will be holistic and ecumenical, focused primarily on improving patient outcomes,” explains Professor Havas.

Another unique aspect of our school will be controlling the commercialisation process. While profit from medical advances is important, it needs to be reframed to become more eco-friendly. This means that a significant amount of profit will not only go to the individuals who own the intellectual property but will be used to support universities and to a lesser extent, hospitals.

“You don’t have to make obscene profits to make medical advances profitable.”

The Head and Neck Cancer Foundation Research Group is already engaging in a multi-disciplinary approach to research. We have been collaborating with biomedical engineers and other scientists for the last three years as evidenced by our research reports.

“What strikes me is that hitherto and in many other areas, how little interaction there is between biomedical engineers and clinicians generally. We bought half a dozen of these students into the operating room and they have never been in an operating room. They are intelligent, they have enormous skill bases that we as clinicians don’t have, but there has been no integrated vision or foresight in terms of bringing the two together,” says Professor Havas.

The School of Translational Medicine will be unique worldwide in its multidisciplinary, inter-disciplinary, problem-focused, and product development-focused approach. As a clinician-led school, it will also include basic scientists, biomedical engineers, and lawyers to teach students about both intellectual property and the commercialisation process.

“The quicker we can bring to market, the quicker it is at the bedside, and the quicker patients benefit,” says Professor Havas.